Guido Uguzzoni - Università degli Studi di Parma #
An inverse model approach to antibodies affinity maturation #
Affinity maturation is a process occurring in the immune system where the antibodies enhances the affinities and the 
neutralization of specific target potentially harmful. This task is achieved by the mutation and the selection against 
the antigen. This evolutionary process produce a repertoire that is suitable of being investigated with statistical 
mechanics tools.
We present some preliminary results of an approach that use inverse model to infer structural features of antibodies 
after the maturation and information of their interactions with the antigen.